SqlException timeout on GetConnection, but only from one node in a cluster

We have two nodes in a cluster. Both run an ASP.NET web application that connects to a database on another s开发者_运维问答erver. Node1 has no problems, but Node2 throws SqlExceptions, stating there's a timeout. The stacktrace shows me it's on DbConnectionPool.GetConnection.

I checked the versions of our DLLs, the web.config files, the connection strings, the MSDTC configuration on the nodes. All are identical.

Any ideas what could be the cause of this?

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It appears the problem was hardware-related. Our client found a router with a hardware defect. After replacing that, all went well again.