Do I need to explicity unload an assembly I loaded dynamically?

I am using some .NET assemblies another developer wrote for use from an older VB6 application. They are only used for some of our customers so I am using the Assembly.LoadFrom(file) method and invoking the methods. I am worried about unloading / releasin开发者_如何学Gog the objects after I make the calls. Do I need to do something explicitly, or will the garbage collector take care of it automatically?

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You can't unload an assembly.

(The closest you can come to that is loading it into an AppDomain that you then unload.)