"Enable HTTP Keep-Alive" in IIS cause disruption?

I have a production web site in IIS 6 where I need to change the value of the "Enable HTTP Keep-Alive" checkbox. Will 开发者_运维问答that cause production disruptions? Recycles, app domain restarts, or similar?

Depending on what you're running (ASP.NET, PHP, etc.), you may or may not see any disruptions but you will see a big hit to your sites' performance.