IIS: There was a problem reading metadata from 'C:\Windows\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files

I am having this most annoying issue when I try to rebuild my solution I get 4 lines of:

There was a problem reading metadata from 'C:\Windows\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET 开发者_如何学CFiles\MyWebSiteName...

I tried restarting IIS, so I could delete the temp files, but they're locked.

How can I fix this annoyance, it only happens on a release build.

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Did you try right-clicking on the Web Project and selecting "Clean"?

Often times if that doesn't work a restart of Visual Studio fixes this.