Flex listen to Operating system events when not in focus

Is there a way that a flex based application (in the browser or AIR) can listen to windows events (or any other OS) when it is not in focus?

Lets say that my AIR开发者_运维百科 application is minimized and I want her to be notified when ever new data was copied to the clipboard?

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No way, otherwise every ad in your browser would be potential keylogger. Not even AIR app can do that out the box. If your AIR app is native, it can run processes - so you could run helper application to watch OS events.